Aspirin
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| Aspirin mechanism of action | Acetylsalicylic acid has antiplatelet, antipyretic, anti inflammatory and analgesic effects.
-inhibits the enzyme cyclooxygenase which results in a reduction in the formation of prostaglandins and thromboxane
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| Indications | -Myocardial ischemia
-STEMI
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| Contraindications (2) | -Know severe allergy
-third trimester of pregnancy
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| Cautions (3) | -know bleeding disorder
-clinically significant bleeding
known worsening of bronchospasm with NSAIDS
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| Dose | 300mg
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| common adverse effects | -increased bleeding
-indigestion, gastrointestinal ulceration/ bleeding associated with long term use
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| Onset | 30-60 minutes
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| Duration | 3-5 days for the antiplatelet activity. platelets exposed to aspirin are impaired for the like of the platelet which is 7-10 days. Approx 10% replaced each day
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| Pharacokinetics | Absorption occurs in the stomach and small intestine.
Metabolised in the liver
no significant effects from liver impairment on acute administration
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| common interactions | displaces warfarin from the binding sites and increases the activity of warfarin.
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