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DRUG ICARDS

Aspirin

QuestionAnswer
Aspirin mechanism of action Acetylsalicylic acid has antiplatelet, antipyretic, anti inflammatory and analgesic effects. -inhibits the enzyme cyclooxygenase which results in a reduction in the formation of prostaglandins and thromboxane
Indications -Myocardial ischemia -STEMI
Contraindications (2) -Know severe allergy -third trimester of pregnancy
Cautions (3) -know bleeding disorder -clinically significant bleeding known worsening of bronchospasm with NSAIDS
Dose 300mg
common adverse effects -increased bleeding -indigestion, gastrointestinal ulceration/ bleeding associated with long term use
Onset 30-60 minutes
Duration 3-5 days for the antiplatelet activity. platelets exposed to aspirin are impaired for the like of the platelet which is 7-10 days. Approx 10% replaced each day
Pharacokinetics Absorption occurs in the stomach and small intestine. Metabolised in the liver no significant effects from liver impairment on acute administration
common interactions displaces warfarin from the binding sites and increases the activity of warfarin.
Created by: nicolaprice01
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