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BC3 - Hematology Info

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Components of Blood   Plasma, Serum, Additional cellular elements  
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Plasma   liquid portion of blood; proteins, lytes, clotting factor but mostly water  
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Serum   Clotting factor is removed; pale yellow  
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Cellular Elements of Blood   Erythrocytes, Leukocytes, Platelets  
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Erythrocytes   RBC - carry O2 & CO2 - help buffer; bioconcave disc shaped; flexible to squeeze; should be bright red and all one size  
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Leukocytes   WBC - defense against infection  
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Platelets   clotting - pieces of cells  
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Erythropoiseis   formation of RBC's ; made in the kidneys; produced when the kidneys detect hypoxia  
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Reticulocytes   Immature RBC's; initially made  
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Lifespan of a RBC   120 days  
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Hemolysis occurs   in the spleen, liver, bone marrow, and lymph nodes; broken down & phagocytized  
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Bilirubin   breakdown product of blood (by-product)  
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Neutrophils   First to arrive; involved in bacterial infection; Produced in 7-14 days; Remain in circulation for 6 hours - very short lived  
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Eosinophils   do not respond to bacterial or viral infection; Allergic response  
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Basophils   Allergic/Inflammatory; Parasitic - do not respond to bacterial or viral infection  
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Monocytes   BIG CELLS - arive 2nd; Can leave circulation and enter tissue - become macrophages  
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Platelets are necessary for   coagulation - they plug holes in body to stop bleeding; made in bone marrow  
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Function of the spleen   Produces RBC's for fetus; Filter - removes old RBC's; Recycles Iron; Stores lymphocytes and monocytes; Stores platelets  
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If spleen is enlarged, it is   under ribs - enlarges downward under left rib cage  
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Lymph System includes   capillaries, ducts, lymph nodes  
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Function of the Lymph System   Carrie fluid from interstitial spaces to blood; Duct empty to veins; Nodes filter bacteria and foreign particles  
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Function of the Liver   Filters dead RBC; Procoagulants - produces clotting factors  
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Geriatric Considerations   tend to loose reserve capacity and RBC's become fragile & don't live long - become anemic; WBC's don't respond as well; have chronic illness = anemia;  
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Children Considerations   RBC's have short life span - don't have same reserve as adults; Inc level of RBC in infants r/t inc need for O2; Increased role of spleen - changes to bone marrow; Newborns & Infants have ^WBC counts  
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Components of a CBC   RBC, Hgb, Hct, Reticulocyte count  
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Components of Differential   MCV, MCH, RBC wt, MCHC, RDW  
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RBC count   4.7-6.1 in males 4.2-5.4 in females  
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Hgb   13.5-17.5 in males 11.5-15.5 in females  
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Hct   40-52 in males 36-48 in females  
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When is a blood transfusion indicated (usually)   Hgb < 8  
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What happens to Hct if patient is dehydrated   elevates  
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What happens to Hct if patient is over hydrated   decreases  
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If neutrophils are low...   patient may need to be on isolation; neutropenic precautions  
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MCV   mean corpuscular volume  
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What is MCV   average cell volume - size "how big"; important for anemia dx  
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MCH   mean corpuscular hemoglobin  
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What is MCH   average cell hemoglobin - dec MCH=dec Hgb  
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RBC weight   weighs the iron in a cell (iron weighs alot)  
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MCHC   ratio of amount of Hgb in cell to volume - proportion; ^MCHC = too much iron; dec MCHC = dec iron  
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RDW   RBC Distribution Width; should be uniform - if ^, something wrong with RBC, possibly anemia  
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Differential Shift refers to   white cells  
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If Bands are immature   immature WBC's - similar to stab cells  
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"Shift to the left"   more immature than mature (acute)  
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If a "shift to the left" is ongoing   indicates an acute bacterial infection  
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Mature Neurtophils indicate a   chronic problem  
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"Shift to the right" indicates   ongoing - increase infection, inflammation, tissue necrosis, leukemic neoplasis, also trauma/stress  
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Sed rate is (def)   the rate at which RBC's settle in solution(  
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What is sed rate used for   a screening tool or to monitor course of illness  
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Increased sed rate can indicate   Inflammation, neoplasm, infection, necrosis  
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What do you worry about with giving a patient blood   the antibody  
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If a patient has Type A blood they have   A antigen; B antibody  
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If a patient has Type B blood they have   B antigen; A antibody  
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If a patient has AB blood they have   A +B antigens; no antibodies  
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Type AB blood is the universal   recipient  
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A patient that has Type O blood has   neither A nor B antigens; A and B antibodies  
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O blood is the universal   donor  
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What is an antigen   something that triggers and immune response  
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Bone Marrow Examinations   iliac crest; done at the bedside; painful - at risk for bleeding; patient is to ly still and apply pressure for 5-10 minutes  
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Normocytic, Normochromic   Normal cell - Normal color; could indicate lost blood  
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Macrocytic, Normochromic   Big cell - normal color; Not hemoglobin or Fe problem; elevated MCV  
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Microcytic, Jypochromic   Small cells - pale color; Could indicate Fe deficiency anemia; decreased MCV  
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