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Clinical Medicine II-Spring 2012

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
How do we diagnose movement disorders   show
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show symptomatic  
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Three classifications of abnl movement   show
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show chorea  
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Twisting, rotational involuntary movement   show
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Myoclonic movement   show
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Where is the parkinson’s belt   show
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show sustantia nigra: dopamine producing cells→by product is melonin linked to parkinson’s movements?  
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With someone is having parkinson’s movements, what should we look for   show
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show both environmental and possibly genetic, not set and stone pathology  
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show ~70 at start of of sxs, slow onset, hard to dx sometimes  
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show resting tremor, bradykinesia, rigidity, posture/balance changes  
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show lewy body dz  
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show supranuclear palsy-no tremor  
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show can’t actually test for it, just r/o other causes, r/I by clinical sxs: give them a PD drug see if +result  
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What is the tx for PD   show
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show nausea, postural hypotension, dyskinesia, motor fluctuations  
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As dz progresses, what happens to sxs   show
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show 3-10yrs post start of levodopa: dyskinesias  
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show high frequency pulsatile, to “ablate” the overactive nerves, targets the nucleus (subthalamic)  
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show middle dz when drugs aren’t nearly as effective, but before in nursing home  
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show REM, constipation, loss of smell  
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show pulmonary infx/aspiration, UTI, PE, complications w/ falls and fxs  
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show Action or postural tremor or kinetic with tasks, can move to rest post action  
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show Hands and voice, usually bilaterally  
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show long duration to dx, Fhx, beneficial response to EtOH  
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show contraction of sternocleidomastoid muscle: torticollis  
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show Genetic, Fhx, Dx: clinical hx, movement tremor,  
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show none, life modifications, wrist weights, biofeedback, BB’s primidone, benzodiazepines, thalamic DBS  
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show Restless legs syndrome  
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Is jerking while sleeping at night RLS?   show
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show idiopathic, or secondary RLS d/t renal failure, DB neuropathy, RA, radiculopathy, preggo, iron def,  
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Pathophysiology of RLS   show
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Why does iron deficiency cause RLS   show
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Tx RLS   show
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Problem with shorter length drugs   show
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When would we use opioids for RLS tx   show
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show Dystonia  
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show only sign, no specific pathology, DYT1 mutation inheritation  
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What is secondary dystonia   show
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show focal, segmental, multifocal, generalized, hemidystonia  
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MC types of focal dystonia   show
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show botox, inject while in a flexed position, just enough to relax/paralysis the muscle good for focal  
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How do we dx dystonia   show
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Dry eye syndrome or tics   show
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show Blepharospasm, cervical dystonia, writer’s cramp  
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show Babinski sign + for spasticity  
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show muscle shortening, motor weakness, + Babinski, muscle overactivity  
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Tx of spasticity   show
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What is poor coordination, examples?   show
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show dysarthria  
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show anytime from many causes  
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Workup of ataxia   show
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DDx of Ataxia   show
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show supportive, assistive devices  
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What diz has chorea or involuntary movements, later dystonia, and voluntary motor dyscontrol, cognitive, and emotional d/o   show
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Dx and patho of HD   show
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show age 30-40, survival about 15-20yo  
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show none, tx sxs: antipsycotic or dopamine antagonists, therapy: PT, OT, speech, nutrition, social services  
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What is the genetic testing for HD   show
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