Clinical Medicine II-Spring 2012
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How do we diagnose movement disorders | show 🗑
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show | symptomatic
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Three classifications of abnl movement | show 🗑
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show | chorea
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Twisting, rotational involuntary movement | show 🗑
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Myoclonic movement | show 🗑
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Where is the parkinson’s belt | show 🗑
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show | sustantia nigra: dopamine producing cells→by product is melonin linked to parkinson’s movements?
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With someone is having parkinson’s movements, what should we look for | show 🗑
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show | both environmental and possibly genetic, not set and stone pathology
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show | ~70 at start of of sxs, slow onset, hard to dx sometimes
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show | resting tremor, bradykinesia, rigidity, posture/balance changes
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show | lewy body dz
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show | supranuclear palsy-no tremor
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show | can’t actually test for it, just r/o other causes, r/I by clinical sxs: give them a PD drug see if +result
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What is the tx for PD | show 🗑
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show | nausea, postural hypotension, dyskinesia, motor fluctuations
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As dz progresses, what happens to sxs | show 🗑
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show | 3-10yrs post start of levodopa: dyskinesias
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show | high frequency pulsatile, to “ablate” the overactive nerves, targets the nucleus (subthalamic)
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show | middle dz when drugs aren’t nearly as effective, but before in nursing home
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show | REM, constipation, loss of smell
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show | pulmonary infx/aspiration, UTI, PE, complications w/ falls and fxs
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show | Action or postural tremor or kinetic with tasks, can move to rest post action
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show | Hands and voice, usually bilaterally
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show | long duration to dx, Fhx, beneficial response to EtOH
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show | contraction of sternocleidomastoid muscle: torticollis
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show | Genetic, Fhx, Dx: clinical hx, movement tremor,
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show | none, life modifications, wrist weights, biofeedback, BB’s primidone, benzodiazepines, thalamic DBS
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show | Restless legs syndrome
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Is jerking while sleeping at night RLS? | show 🗑
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show | idiopathic, or secondary RLS d/t renal failure, DB neuropathy, RA, radiculopathy, preggo, iron def,
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Pathophysiology of RLS | show 🗑
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Why does iron deficiency cause RLS | show 🗑
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Tx RLS | show 🗑
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Problem with shorter length drugs | show 🗑
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When would we use opioids for RLS tx | show 🗑
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show | Dystonia
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show | only sign, no specific pathology, DYT1 mutation inheritation
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What is secondary dystonia | show 🗑
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show | focal, segmental, multifocal, generalized, hemidystonia
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MC types of focal dystonia | show 🗑
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show | botox, inject while in a flexed position, just enough to relax/paralysis the muscle good for focal
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How do we dx dystonia | show 🗑
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Dry eye syndrome or tics | show 🗑
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show | Blepharospasm, cervical dystonia, writer’s cramp
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show | Babinski sign + for spasticity
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show | muscle shortening, motor weakness, + Babinski, muscle overactivity
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Tx of spasticity | show 🗑
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What is poor coordination, examples? | show 🗑
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show | dysarthria
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show | anytime from many causes
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Workup of ataxia | show 🗑
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DDx of Ataxia | show 🗑
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show | supportive, assistive devices
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What diz has chorea or involuntary movements, later dystonia, and voluntary motor dyscontrol, cognitive, and emotional d/o | show 🗑
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Dx and patho of HD | show 🗑
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show | age 30-40, survival about 15-20yo
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show | none, tx sxs: antipsycotic or dopamine antagonists, therapy: PT, OT, speech, nutrition, social services
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What is the genetic testing for HD | show 🗑
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