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Leukemia + Lymphoma

TermDefinition
Acute Lymphocytic Leukemia (ALL) Aggressive, more common in children Faster response, better treatment Philadelphia chromosome (9+22) Immature T and B cells (lymphoblasts) Signs- Anemia, increased bleeding, lymph node enlargement, splenomegaly, infection risk 1, bone pain, CNS
Chronic Lymphocytic Leukemia (CLL) Most common type in US Over 70, male agents that disrupt DNA important (ZAP-7) - Postitive bad, negative good B-Cell malignancy B-CLL = protooncongene bcl2 typical signs WBC >20,000 (lymphocytosis) smudge cells, bone marrow biopsy
Acute Myelogenous Leukemia (AML) Proliferation of undifferentiated myeloid blast cells MB can invade other tissues Risk if chemotherapy or radiation for cancers Oncongenes, FLT 3, c-KIT Chromosome 8 + 12 common Typical signs
Chronic Myelogenous Leukemia (CML) Overproduction of mature myeloid cells 65+ Philadelphia Clinical Course: 1- chronic :Neutrophils lose differentiation 2- accelerated: Neutrophils more undifferentiated 3- Blast Crisis: MB dont differentiate, spread Typical Signs WBC >100000
Non-Hodgkin's Lymphoma (NHL) B, T, NK cells - 30 subtypes Middle aged or older, men 14 +18 chromosomal translocation HIV, Hep C, H.pylori associated Immunosuoppresive treatment may increase NHL risk enlarged, painless lymph node first sign
Hodgkin's Lymphoma (HL) B cell - 5 subtypes Most common young adults and children over 10 years of age Unknown cause may play a role, EBV Reed-Sternberg cells: malignant B cell with two nuclei (Owl Eyes) No dramatic symptoms, enlarged lymph node present
Created by: Mplaster
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