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__% of infants develop jaundice in the 1st week
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Jaundice that appears on days 2-3 and disappears by day 7 (day 14 if premature) is called:
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Jaundice
Pediatrics
| Question | Answer |
|---|---|
| __% of infants develop jaundice in the 1st week | 65 |
| Jaundice that appears on days 2-3 and disappears by day 7 (day 14 if premature) is called: | Physiologic jaundice |
| __ fed babies are at higher risk for physiologic jaundice | Breast |
| Jaundice with bilirubin >5mg/dL | Clinical jaundice |
| What is the bodily progression of jaundice | Cephalocaudal: starts at the head and moves down |
| In elevated conjugated bilirubin, suspect: | biliary atresia |
| Unconjugated hyperbilirubinemia that results from increase in RBC destruction (antibody mediated hemolysis) is Coombs: | positive |
| Non-immune hemolysis is Coombs: | Negative |
| How does phototherapy work for unconjugated hyperbilirubinemia? | Unconjugated bilirubin in skin is converted to water soluble isomers that are excreted without conjugation |
| Risks for physiologic jaundice | Preterm. Affected sibling. Asian > white > AA. Breastfeeding-associated jaundice is common. Tx = phototherapy |
| Pathologic unconjugated bilirubinemia: causes related to increased production: | Increased RBC destruction due to antibody-mediated hemolysis (ABO or Rh incompatibility). Nonimmune (hereditary spherocytosis, G6PD, cephalohematoma, polycythemia, ileus ). |
| Pathologic unconjugated bilirubinemia: causes related to decreased conjugation rate | UDPGT deficiency. Crigler-Najar syndrome. Gilbert syndrome. |
| Gives a direct reaction in the van den Bergh test: | Conjugated bilirubin |
| Can cross placenta & is conjugated by mom’s enzymes | indirect/unconjugated bili |
| Water-soluble; placenta is impermeable to: | Direct/conjugated bili |
| Serious, rare, permanent deficiency of glucuronosyltransferase that results in severe indirect hyperbilirubinemia | Crigler-Najjar syndrome |
| Unconjugated bili without hemolysis (usually ≤20 mg/dL) is likely to be due to: | Breast milk jaundice |
| Jaundice >2 wks after birth = | Pathologic; probably direct bilirubinemia (DBil >2 or >20% of TBil) |
| Begin phototherapy when indirect bili = | 16-18 mg/dL |
| Conjugated hyperbilirubinemia is always: | pathologic |
| Jaundice involving the face: total serum bili is approximately: | 5 mg/dL |
| Jaundice involving the abdomen: total serum bili is approximately: | 15 mg/dL |
| Jaundice involving the feet: total serum bili is approximately: | 20 mg/dL |
Created by:
Abarnard
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