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AML

QuestionAnswer
What are the types of translocation is AML associated with? t(8;21) - RUNX, inv(16), t(15;17) - APL --> Down Syndrome, t(9,11)
What is the median age for onset of AML? 65 years
What is the cytoplasmic granule of AML? Auer Rods
What are the CD Positivity? CD 13,14 and CD33 positive
Which type of translocation is a favourable prognosis? t(8; 21) - RUNX
What are the clinical findings Acute Promyelocytic Leukemia? 1. Disseminated intravascular coagulation due to the release of thrombotic substance into the granules. 2. Younger age (median age 35-40). 3. t(15;17) translocation - APL-RAR
What Tx can be used for Acute Promyelocytic leukemia or T(15:17)? All-trans retinoic acid (ATRA) can overcome the translocation.
Created by: Jameel D. Wilson
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