● dependent on combination of genetic predisposition and factors of environment or life style influencing manifestation of the disease b
- obesity and insulin non-dependent diabetes mellitus - combination of genetic predisposition with nutritional habits and low physical activity
Adaptation capacity b
it is !!!very individual!!! - dependent on:- genetic disposition- age
● largely dependent on environment or life style
- Malaria - only in countries with mosquitoes transmitting Plasmodium
Adaptation capacity f
high external temperature requires thermoregulatory response based on peripheral vasodilation → ↓ BP - to keep adequate BP requires ↑ MV, people with chronic heart failure do not have
Disease may be dependent:● exclusively on genetic factors without any possibility to influence its appearance:
- Lung cancer - due to smoking (low in Mormons and Seventh day Adventists with code against use of tobacco – but non-smokers also can have lung cancer!!)- Skin cancer - due to ultraviolet light
Adaptation capacity a
represents adaptability of the body- can be expressed as a range of external environment parameters within which the particular organism can keep homeostasis (survive)
● dependent on combination of genetic predisposition and factors of environment or life style influencing manifestation of the disease
most frequent case- early coronary heart disease - due to predisposition to hypercholesterolemia and simultaneous high animal fat intake and/or smoking, low physical activity, stress factors etc.
● largely dependent on environment or life style
- Colon cancer - low in developing countries (e.g. Africa), high in "westernized" populations (USA, Europe) - due to different intake of dietary fibers and fat
Factors influencing organism b
● factors from environment - viral and microbial - chemical (toxins, drugs, allergens) - physical (irradiation, temperature, sun exposure, altitude - p02)● psychological factors (family background, stress, religion etc.)
