RPE
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| show | monolayer of polarized CUBOIDAL epithelial cells. it separates the photoreceptors from their blood supply (choroidal vasculature)
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| show | 1.ABSORPTION of stray light to enhance visual acuity 2.PROTECTION against toxic and oxidative damage 3.FORMATION of the blood- retina- barrier 4.SELECTIVE TRANSPORT of substances to/from neural retina 5.ELIMINATION of metabolic waste 6. PROCESSING of vit
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| show | 4 to 6 million cells in a hexagonal pattern
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| show | GREATEST: fovea LOWEST: periphery
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| show | they face ~30-40 photoreceptors. PHAGOCYTIZE shed discs of photoreceptor outer segments on a daily basis
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| show | pigmented epithelium of the ciliary body
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| How are the neural retina and RPE arranged? | show 🗑
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| show | potential space seaparating the RPE from photoreceptor
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| show | APEX: inward (towards vitreous) BASAL: faces outward (towards schlera)
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| show | inner most layer of Bruch's membrane of choroid
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| show | extends numerous microvilli into the space between RPE from photoreceptors (subretinal space) that interlock with the rod outer segments
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| show | located between the apical membrane and photoreceptors. it keeps the APICAL MICROVILLI and PHOTORECEPTOR OUTER SEGMENTS bound together, but no junctional attachments occur. it also exchanges metabolites and interactions between the photoreceptors and RPE
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| show | they phagocytize the discs of the photoreceptor outer segments and can be seen in the cytoplasm of the RPE as phagosomes
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| show | they are gradually digested by intracellular enxymes and their end products are 1. deposited on Bruch's membrane (drusen) or 2. stay within the cell as lipofuscin grandues
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| show | increase
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| show | RODS: early morning CONES: end of the day
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| show | once every 8-13 days
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| show | in the APICAL membrane: NA-K-ATPase. but other transport epithelia have this system in the basolateral PM. this system helps regulate fluid fluzes that contribute to the adhesion of neurosensory retina to the RPE
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| show | zonular occluden is more apical in this membrane. it is the junction that destroys the space between adjacent RPE cells that form blood- retina- barriers.
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| What is special about the basal membrane of the RPE? | show 🗑
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| Where does drusen deposit? | show 🗑
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| The deposits of metabolic waste on Bruch's membrane make it? | show 🗑
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