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BIO201-Ch9-Muscles 1
BIO201 - Ch 9 - Muscles & Muscle Tissue - Marieb/Hoehn - RioSalado - AZ
Question | Answer |
---|---|
Muscle tissue makes up nearly __ of body mass. | Nearly half |
What is the most distinguishing functional characteristic of muscles? | Ability to change ATP into directed mechanical energy. |
There are __ types of muscle tissue. Name them. | 3 - Skeletal, cardiac, & smooth. |
Origin | End of a muscle attached to bone - doesn't move much. |
Insertion | Other side of muscle attached to bone that moves most. |
Synergistically | Working together. |
Antagonistically | Works in opposition. |
Actin | Globular protein that can contract. |
Myosin | Protein with two heads & a tail. |
Skeletal & smooth muscle cells - not cardiac - are elongated & called __. | Muscle Fibers. |
Muscle contraction depends on two kinds of __. | Myofilaments |
Meaning of prvixes "myo" or "mys". | "Muscle" |
Meaning of prefix "sarco" | "flesh" in relation to muscles. |
Sarcolemma | Plasma membrane of muscle fibers. |
Sarcoplasm | Muscle fiber cytoplasm |
Organs that attach to & cover bony skeleton. | Skeletal muscles. |
Longest muscle cells. | Skeletal muscle fibers. |
3 keywords regarding skeletal muscle tissue? | Skeletal, striated, & voluntary. |
Which muscle can contract rapidly, but tires easily? | Skeletal muscle - must relax. |
Keywords to remember for cardiac muscle. | Cardiac, striated, involuntary. |
What usually sets the steady rate of heart beats? | Heart's pacemaker. |
What allows heart to "shift into high gear" briefly? | Neural controls |
What is the role of smooth muscle tissue? | Force fluids & etc through body channels. |
Keywords for smooth muscles? | Visceral, nonstriated, & involuntary. |
What muscle tissue have slow & sustained contractions? | Smooth muscle tissue. |
5 functional characteristics of muscle tissue. | Excitability, responsiveness, contractility, extensibility & elasticity. |
Excitability/responsiveness refers to? | Ability to receive & respond to a stimulus. |
Give an example of excitability. | Contraction as a result of receiving an electrical impulse from a nerve cell. |
Which function characteristic sets muscle apart from all other tissue types? | Contractility - ability to shorten forcibly when adequately stimulated. |
Define "extensibility". | The ability to be stretched or extended. |
4 important functions performed by muscles. | Movement, maintains posture, stabilized joints, & generates heat. |
When do muscles generate heat? | As they contract. |
How do smooth muscles protect organs? | They form valves to regulate substance passage. |
How do skeletal muscles protect organs? | By enclosure. |
List the 6 levels of organization of skeletal muscles. | Myofilament=>sarcomere=>myofibril=>muscle fiber (cell)=>fascicle=>muscle |
Each skeletal muscle is a descrete __. | Organ |
In general, each muscle is served by __. | 1 nerve, 1 artery, 1 or more veins that enter/exit near center & branch out. |
Each skeletal muscle fiber is supplied with a __. | Nerve ending that controls its activity. |
Individual muscle fibers are wrapped & held together by several different __. | Connective tissue sheaths. |
What prevents bulging muscles from bursting during exceptionally strong contractions? | Strong connective tissue sheaths. |
Endomysium surrounds what? | Each muscle fiber. |
What is endomysium comprised of? | Areolar & reticular fibers. |
Endomysium-wrapped muscle fibers are grouped into __. | Fascicles. |
What fibrous CT surrounds each fascicle? | Perimysium. |
Epimysium surrounds the __. | Whole muscle. |
Epimysium is? | A dense "overcoat" of dense, irregular CT surrounding whole muscle. |
Epimysium sometimes blends with what? | Deep fascia between muscles or superficial fascia deep to the skin. |
When muscle fibers contract, they pull on __ which transmits pulling force to the bone to be moved. | Connective tissue sheaths of skeletal muscle. |
What are the "series elastic components?" | Connective tissue sheaths because they contribute to the natural elasticity of muscle tissue. |
The thick myofilaments contain __. | Bundled myosin molecules. |
The thin filaments contain __. | Actin molecules. |
What maintains the organization of the A band & provides for elastic recoil? | Elastic filaments. |
Which molecule of the myofilament has "heads"? | Myosin molecule. |
What is a segment of a myofibril called? | A sarcomere - section between 2 Z-lines - functional unit. |
What is the contractile unit of a muscle? | The sarcomere - made of myofilaments of contractile proteins. |
A myofibril or "fibril" is composed of ? | Myofibrils that are composed of sarcomeres arranged end-to-end. |
Complex organelle composed of myofilament bundles. | Myofibril or fibril. |
A muscle cell is also called a __. | Muscle fiber. |
A muscle cell is surrounded by __. | Endomysium. |
A discrete bundle of muscle cells surrounded by perimysium. | A fascile. |
Consists of hundreds to thousands of muscle cells. | A muscle. |
In limb muscle, the origin typically lies __ to the insertion. | Proximal |
Muscle attachments may be __ or __. | Direct or indirect. |
In direct or flashy attachments __. | The muscle epimysium is fused to the periosteum of bone or perichondrium of cartilage. |
In indirect attachments __. | CT of msucle tissue wrappings extends as tendons or sheet-like aponeurosis. |
Tendons or aponeurosis anchor muscle to __. | CT covering bone or cartilage or fascia of other muscles. |
Which type of muscle attachment is more common & why? | Indirect attachments - because of their durability & small size. |
Tendons conserve __. | Space |
Compared to other cells, the diameter of a muscle cell is __ larger. | 10 times |
Each muscle cell is produced by the fusion of __. | Hundreds of embryonic cells. |
The sarcoplasm of muscle fiber contains unusual amounts of __. | Glycosomes (stored glycogen) & myoglobin. |
Myoglobin | Red pigment that stores oxygen. |
Each muscle fiber contains 100-1000's of rod-like __. | Myofibrils |
Myofibrils account for about __% of cellular volume. | 80% |
Striations are a repeating series of __. | Dark A bands & light I bands. |
H Zone | Helle - "bright" zone - lighter stripe in middle of A band. |
M Line | "Middle" line - a dark line that bisects H zone. |
Z line or Z disc | Midline interruption of I band. |
The functional units of skeletal muscles. | Sarcomeres. |
__ filaments extend whole length of A band. | Thick |
__ filaments extend across the I band & part of A band. | Thin |
The banding pattern of myofibril arises from __. | Orderly arrangement of myofilaments. |
The Z disc is composed largely of __. | The protein alpha actinin. |
__ filaments connect each myofibril to the next. | Intermediate (desmin) filaments at Z disc. |
The H zone of A band appear less dense why? | Because the thin filaments do not extend in to this region. |
The M line in center of H zone is darker why? | Presence of fine protein strands that hold thick filaments together. |
Myofilaments are connected to sarcolemma at __ & the __. | Z discs & M lines. |
Each thick filament is surrounded by __. | 6 thin filaments. |
Each thin filament is enclosed by __. | Three thick filaments. |
Each mysoin molecule has __. | Rod-like tail & 2 globular heads. |
Each myosin tail consists of __. | Two interwoven helical polypeptide chains. |
The globular heads of myosin link __. | Thick & thin filaments together - crossbridges. |
During contraction, globular heads __ around their point of attachment. | Swivel. |
Cross bridges act as __ to generate tension. | Motors |
Each thick filament contains about __ myosin molecules. | About 300 |
What coils around the helix actin strands & reinforces them? | Tropmyosin Molecules |
The heads of myosin contain __ enzymes. | ATPase - they split ATP to generate energy. |
In the string of pearls design of actin, __ are the pearls and __ is the string. | Globular (G) actin, Fibrous (F) actin. |
What protien in actin core blocks myosin binding sites? | Tropomyosin |
__ is a 3-polypeptide complex involved in myosin-actin contraction interactions. | Troponin |
The elastic filament is made of the protein __. | Titin |
Which filament holds the thick filament in place & assists muscle cell to spring back into shape? | Elastic filament. |
Sliding filament model | Thin slides past thick & overlap - myosin filaments slide & pull actin towards the center of sacromere. |
3 Metabolic pathways for muscles. | (1) Dephosphorylation of creatine phosphate,(2) glycolysis, (3) aerobic respiration. |
Sarcoplasmic Reticulum (SR) | Surrounds muscle cell's myofibrils - takes up & releases calcium ions - smooth ER. |
T tubules | Tube-like extensions of muscle cell's plasma membrane where neural signals are received. |
T tubules occur where? | At each A band-I band junction. |
What giant protein stiffens as it uncoils & helps the muscle to resist excessive stretching? | Titin |
What keeps the sarcomeres from being pulled apart? | The giant protein titin. |
What protein links the thin filaments to the integral proteins of the sarcolemma? | Dystrophin |
Skeletal muscle cells contain which 2 sets of intracellular tubules? | The sarcoplasmic reticulum & T tubules. |
The perpendicular cross channels of the SR are __. | Terminal cisternae ("End sacs"). |
The major role of the SR is to __. | Regulate intracellular levels of ionic calcium. |
What are the triads? | Structure formed by a T tubule w/a SR cisterna on either side. They form the excitation-contraction coupling. |
Name the triads | Terminal cisterna, T tubule, Terminal cisterna |
Muscle contraction is ultimately controlled by? | Nerve-initiated electrical impulses that travel along the sarcolemma. |
T tubules are continuations of the __. | Sarcolemma |
T tubules conduct impulses to the __ & to every __. | Deepest regions of muscle cells/ every sarcomere. |
T tubules ensure that every myofibril __ at the same time. | Contracts |
What is known as the "double zipper" of integral proteins that protrude into the intermembrane spaces of T tubule? | DHP receptors |
DHP receptors act as __. | Voltage sensors. |
The "foot proteins" of the SR do what? | Form channels so Ca 2+ can be released from SR cisternae. |
Contraction refers to __. | Activation of myosin's cross bridges. |
Shortening occurs when __ generated by cross bridges exceeds the __. | Tension/forces opposing shortening. |
In relaxed muscle fiber, thin-thick overlap is minimal & occurs __. | Only at ends of A band. |
When muscle fibers are stimulated, __ latch on to __ & the sliding begins. | Myosin heads/myosin binding sites on actin. |
During contraction, Z discs are pulled __ thick filaments. | Toward |
Which zone disappears during contraction? | H zone |
Which bands do not change their length during contraction? | A bands - only move closer together. |
Which structure contains highest Ca 2+ in resting muscle cell? | SR - it is a Ca storage depot. |
To contract, an action potential must propagate along a muscle cell's __. | Sarcolemma - causes rise in Ca ion levels. |
Somatic motor neurons activate __. | Skeletal muscle cells. |
Ending of motor neuron axon forms curling branches w/muscle fiber & is called __ | Neuromuscular junction |
As a rule, each muscle has only one __ located midway along the fiber's length. | Neuromuscular junction - only one. |
The __ is teh space separating the axon terminal & muscle fiber. | Synaptic cleft. |
__ are small sacs at axon terminals that contain acetylcholine. | Synaptic vesicles. |
The __ or junctional folds in the sarcolemma help form neuromuscular junctions & provide large surface area for ACh receptors. | Motor end plate |
ACh receptors are located where? | At themotor end plate/junctional folds. |
What happens when impulse reaches end of axon? | Voltage-gated calcium channels open. |
What does the presence of CA inside axon terminal cause? | Release of ACh into synaptic cleft by exocytosis. |
ACh diffuse across synaptic cleft & attaches to ACh receptors on the __. | Sarcolemma, where the receptors are. |
What prevents continued muscle contraction in absence of nervous sys. stimulation? | Destruction of ACh by acetylocholinesterase enzyme. |
What is destroyed by the autoimmune disease, myasthenia gravis? | ACh receptors - muscle weakness. |
T tubules are inward __ of the sarcolemma. | Invaginations |
Binding of ACh molecules to ACh receptors at motor end plate opens __ & allows __ & __ to pass. | Chemically (ligand) gated ion channes. - Both Na+ & K+ |
Depolarization | When interior of sarcolemma becomes slightly less negative as Na+ & K+ diffuse out. |
End plate potential | Local depolarization |
3 Steps of action potential across sarcolemma | (1) Depolarization & gates open, Na+ enters (AP gen.), (2) Propagation of AP along sarcolemma, (3) repolarization as Na+ channels close & K+ open. |
Cells cannt be stimulated again until __ is complete. | Repolarization |
During repolarization, muscle fiber is said to be in __. | Refractory period. |