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BIO202-CH16-cAMP
BIO202 - CH16 - Cyclic AMP - Marieb/Hoehn - RioSalado - AZ
Question | Answer |
---|---|
What is cyclic AMP? | Intracellular 2nd messenger - mediates effects of 1st (extracellular) messenger; formed from ATP by membrane enzyme (adenylate cyclase). |
Except for thyroid hormone, all amino-acid based hormones exert their signaling effects through __. | intracellular 2nd messengers |
Name the 3 plasma membrane components that interact in cyclic AMP (cAMP). | Hormone receptor, G protein (signal transducer) & adenylate cyclase (effector enzyme) |
What is the first messenger in cyclic AMP signaling? | The hormones binding to its receptor |
What does the binding of a hormone cause in cAMP signaling? | The receptor to change shape & bind to G protein |
G protein is activated as __ is displaced by high energy compound __. | GDP (guanosine diphosphate), GTP (guanosine triphosphate) |
G protein behaves like a light switch. It is off when __ is bound to it & on when __ binds. | GDP, GTP |
Activated G protein binds to what? | the effector enzyme adenylate cyclase |
G proteins can __ or __ adenlyate cyclase. | stimulate or inhibit |
If activated, adenylate cyclase generates __. | cAMP (2nd messenger) from ATP |
cAMP triggers activation of __. | Protein Kinase A |
What are protein kinases? | Enzymes that phosphorylate (add phosphate group) various proteins |
Active protein kinase A triggers what? | Responses of target cell - opens ion channels, activates, enzymes, etc. |
Each activated adenylate cyclase generates __. | Large #s of cAMP molecules & can catalyze 100s of reactions. |
Theoretically, one hormone molecule binding can generate __. | millions of final product molecules. |
cAMP is rapidly degraded by __. | phosphodiesterase - intracellular enzyme |
Since phosphodiesterase rapidly destroys cAMP, continued cellular activity is prompted by __. | continued production of hormones. |
Some G proteins inhibit adenylate cyclase & __. | reduce cAMP concentration. |